This deliverable, titled D10.1 EU-oncDST, is one of the outcomes of Work Package 10 (WP10) on oncology decision support tools (oncDSTs) within the CAN.HEAL project under the EU4Health Programme. It introduces the EU-oncDST concept, a digital framework that facilitates the implementation and interoperability of oncDSTs to support the management of oncological processes and drive further advancements in the field. The framework aims to support Molecular Tumor Board (MTB) operations across institutional, national, and European levels. The concept was developed based on consultations within CAN.HEAL, insights from a European survey, and a mapping exercise of oncDST solutions, encompass contributions from the private sector as well as national and European initiatives.