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VERMEER FCM: A tool integrating exposure and hazard modelling for chemicals migrating from food contact materials.

Selvestrel, G
Ciffroy, P
Manganaro, A
Alfonso, B
Benfenati, E
Manganelli, S
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Abstract

A new tool, VERMEER FCM, was developed to support the risk assessment of single organic chemicals migrating from plastic food contact materials (FCM). The freely available tool is integrated into MERLIN-Expo and has been designed in line with Regulation (EU) No 10/2011 for plastic FCM. Overall, the tool consists of three modules that allow (i) to model the migration of chemicals into food, (ii) to predict toxicological endpoints relevant to risk assessment of FCM chemicals, and (iii) to automatically check whether the chemical of interest is included in Regulation (EU) No 10/2011. To apply the VERMEER FCM tool, users need to provide information regarding the chemical(s) of interest, the FCM, the food and other parameters (e.g. contact time and temperature). The three modules can be run either separately or in combination. Migration is predicted by a recently developed migration model, whereas hazard predictions for genotoxicity, subchronic toxicity, reproductive and developmental toxicity and carcinogenicity are provided by QSAR models selected from the publicly available VEGA HUB. The major novelty of the tool is that it combines information on hazard and exposure (i.e. migration) with regulatory information. Several case studies were performed to demonstrate the application of the tool.

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2024-11-01
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Peer reviewed scientific article
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Keywords
Food Contamination, Food Packaging, Humans, plastics, Quantitative Structure-Activity Relationship, Risk Assessment
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