Differential modulations of striatal tyrosine hydroxylase and dopamine metabolism by cannabinoid agonists as evidence for functional selectivity in vivo.
Bosier, B. Muccioli, G.G. Sarre, S. Michotte, Y. Lambert, Didier M. Hermans, E.
Bosier, B.
Muccioli, G.G.
Sarre, S.
Michotte, Y.
Lambert, Didier M.
Hermans, E.
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Abstract
It is generally assumed that cannabinoids induce transient modulations of dopamine transmission through indirect regulation of its release. However, we previously described a direct cannabinoid-mediated control of tyrosine hydroxylase (TH) expression,
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2012-02-13
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Peer reviewed scientific article
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access, Activity, Adult, Agonist-selective coupling, analysi, analysis, AS, brain, cause, CB1 cannabinoid receptor, Control, data, Dopamine, DRUG, effect, effects, evidence, exposure, expression, Functional, G protein, GPCR, Increase, IS, metabolism, metabolites, rats, Reduction, regulation, report, response, structure, System, Transmission, trend, Tyrosine hydroxylase