Increased vancomycin susceptibility in mycobacteria: a new approach to identify synergistic activity against multi-drug resistant mycobacteria
Rens, C. Wang, X.M. De Bruyn, J. Lanéelle, M.A. Laval, F. Lemassu, A. Daffe, M. Bifani, P. Fontaine, V.
Rens, C.
Wang, X.M.
De Bruyn, J.
Lanéelle, M.A.
Laval, F.
Lemassu, A.
Daffe, M.
Bifani, P.
Fontaine, V.
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Abstract
Mycobacterium tuberculosis is wrapped in complex waxes, impermeable to most antibiotics. Comparing M. bovis BCG and M. tuberculosis mutants, lacking phthiocerol dimycocerosates (PDIM) and/or phenolic glycolipids, with wild-type strains, we observed that glycopeptides strongly inhibited PDIM deprived mycobacteria. Vancomycin together with a drug targeting lipids synthesis inhibited multidrug-resistant (MDR) and extensively-drug resistant (XDR) clinical isolates. Our study puts glycopeptides in the pipeline of potential anti-TB agents and might provide a new antimycobacterial drug-screening strategy
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2015-08-15
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Peer reviewed scientific article
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Activity, Agent, Agents, Antibiotic, antibiotics, approach, approaches, article, BCG, Belgium, Biology, Brussels, Bruxelles, Clinical, comparing, de, disease, Diseases, DRUG, electronic, France, health, Hygiene, identify, INFECTION, Infectious, Infectious diseases, Institute, IS, journal, Lipids, M, microbiology, Mycobacterium, Mycobacterium tuberculosis, observed, pharmacology, public, public health, Public-health, strain, Strategies, Strategy, study, Tuberculosis, Universities, university, Vancomycin, WIV-ISP