To improve the practice of therapeutic drug monitoring, the Belgian Health Authorities have decided to support the development of an upgraded version of a pharmacokinetic program, so-called PharMonitor 1.0.0. Based on the Sawchuk-Zaske method, this software is a valuable and user-friendly tool for individually adjusting dosage regimens of aminoglycosides. It allows maximal speed, flexibility, reliability and optimal traceability. Moreover, the software is easily customized according to the user's selection (language, concentration units, drug target ranges, creatinine clearance, ...). Reports can be generated in PDF format after appropriate validation. The software can be connected to most laboratory information systems. Additional applications should be developed on PharMonitor 1.0.0. (other classes of drugs, Bayesian approach, ...). Once freely distributed to all Belgian laboratories, this software is expected to reduce the variability observed through external quality assessment schemes (EQAS), in the interpretation of drug concentrations