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T cell reactivity against mycolyl transferase antigen 85 of M. tuberculosis in HIV-TB coinfected subjects and in AIDS patients suffering from tuberculosis and nontuberculous mycobacterial infections

Launois, P.
; 
Drowart, A.
; 
Bourreau, E.
; 
Couppie, P.
; 
Farber, C.M.
; 
Van Vooren, J.P.
; 
Huygen, K
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Abstract

The mycolyl transferase antigen 85 complex is a major secreted protein family from mycobacterial culture filtrate, demonstrating powerful T cell stimulatory properties in most HIV-negative, tuberculin-positive volunteers with latent M.tuberculosis infection and only weak responses in HIV-negative tuberculosis patients. Here, we have analyzed T cell reactivity against PPD and Ag85 in HIV-infected individuals, without or with clinical symptoms of tuberculosis, and in AIDS patients with disease caused by nontuberculous mycobacteria. Whereas responses to PPD were not significantly different in HIV-negative and HIV-positive tuberculin-positive volunteers, responses to Ag85 were significantly decreased in the HIV-positive (CDC-A and CDC-B) group. Tuberculosis patients demonstrated low T cell reactivity against Ag85, irrespective of HIV infection, and finally AIDS patients suffering from NTM infections were completely nonreactive to Ag85. A one-year follow-up of twelve HIV-positive tuberculin-positive individuals indicated a decreased reactivity against Ag85 in patients developing clinical tuberculosis, highlighting the protective potential of this antigen

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2011-07-01
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Peer reviewed scientific article
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Acyltransferases, AIDS-Related Opportunistic Infections, Antigens, Antigens,Bacterial, article, Belgium, Cell, Clinical, complications, culture, developing, disease, electronic, families, Family, Follow up, FOLLOW-UP, French Guiana, Group, HIV, HIV Infections, Humans, im, Immunologic Memory, immunology, Individuals, INFECTION, infections, Interferon-gamma, IS, journal, Lymphocyte Activation, M, metabolism, microbiology, Mycobacterium, Mycobacterium Infections, Mycobacterium tuberculosis, Nontuberculous Mycobacteria, Patient, patients, physiology, protein, Research, Research Support, response, Responses, SB - IM, Switzerland, Symptom, Symptoms, T-Lymphocytes, Tuberculin Test, Tuberculosis, Tuberculosis,Pulmonary, Universities, university, virology, Volunteers
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https://hdl.handle.net/20.500.14493/9665
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