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Very Long Persistence of Botulinum Toxin B in a Patient’s Serum

De Weweire, Mieke
Dierick, Katelijne
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Abstract

Background:

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Botulinum toxins (BoNT) type A, B, E, F may induce a serious neuroparalytic illness in humans. Botulism can be transmitted via

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three routes: foodborne, wound and intestinal (in situ toxemia generally observed in infants and/or in immunocompromised adults)

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botulism.

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Case Report:

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A case of human botulism type B due to the consumption of an imported dried ham is reported. Laboratory results confirmed the

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diagnosis using the mouse bioassay and the qPCR method. Botulinum toxin was still detected in the serum up to 29 days after food

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consumption while it was not detected anymore in the faeces.

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Conclusion:

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The described case highlights i) prolonged presence of BoNT B in the serum and ii) the risks related to the preparation of artisanal

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products as well as the importance of an efficient communication to citizens regarding preservation methods of household products.

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2018-07-01
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Peer reviewed scientific article
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Keywords
Bioassay, BoNT, Botulinum neurotoxins, Botulism, Clostridium botulinum, Immunocompromised
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