Based on the sentinel surveillance networks for influenza-like illness (ILI) and severe acute respiratory infections (SARI), the 2021-2022 season was characterized by the return of seasonal influenza viruses, cause an epidemic wave in Spring, so later than pre-COVID season. Seasonal influenza A viruses of the H3N2 subtype clearly dominated over the H1N1 subtype and the influenza B viruses. SARS-CoV-2 virus continued to intensively circulate during the whole period with several epidemic waves occurring throughout the season. Respiratory syncytial virus was not responsible for a true epidemic wave this season. Other respiratory viruses such as metapneumoviruses, parainfluenza viruses, seasonal coronaviruses, rhino- and enteroviruses, and adenoviruses were also regularly detected, without clear epidemic wave.