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Effectiveness of XBB.1.5 Monovalent COVID-19 Vaccines During a Period of XBB.1.5 Dominance in EU/EEA Countries, October to November 2023: A VEBIS-EHR Network Study.

Monge, Susana
Humphreys, James
Nicolay, Nathalie
Holm Hansen, Christian
Emborg, Hanne-Dorthe
Sacco, Chiara
Mateo-Urdiales, Alberto
Castilla, Jesús
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Abstract

Using a common protocol across seven countries in the European Union/European Economic Area, we estimated XBB.1.5 monovalent vaccine effectiveness (VE) against COVID-19 hospitalisation and death in booster-eligible ≥ 65-year-olds, during October-November 2023. We linked electronic records to construct retrospective cohorts and used Cox models to estimate adjusted hazard ratios and derive VE. VE for COVID-19 hospitalisation and death was, respectively, 67% (95%CI: 58-74) and 67% (95%CI: 42-81) in 65- to 79-year-olds and 66% (95%CI: 57-73) and 72% (95%CI: 51-85) in ≥ 80-year-olds. Results indicate that periodic vaccination of individuals ≥ 65 years has an ongoing benefit and support current vaccination strategies in the EU/EEA.

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2024-04-01
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Peer reviewed scientific article
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Keywords
Aged, Aged, 80 and over, COVID-19, COVID-19 Vaccines, Electronic Health Records, Europe, European Union, Female, Hospitalization, Humans, Male, Retrospective Studies, SARS-CoV-2, Vaccination, Vaccine Efficacy
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Coronavirus #22355#
Infectious disease #22106#
Post-authorisation surveillance of COVID-19 vaccines #12197#
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