Rapid analysis of melamine residue in milk, milk products, bakery goods and flour by ultra-performance liquid chromatography/tandem mass spectrometry: From food crisis to accreditation
Hanot, V. Halbardier, J.F. Michelet, J.Y.
Hanot, V.
Halbardier, J.F.
Michelet, J.Y.
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Abstract
A simple and rapid ultra-performance liquid chromatographic (UPLC) method with tandem mass spectrometry has been developed and validated for the determination of melamine in milk, milk products, bakery goods, and flour. The method comprises a simple extraction step with a solution of acetonitrile-water, ultrasound treatment and a liquid-liquid extraction with dichloromethane for fat removal. The purified extract is further diluted before injection on a ACQUITY BEH Hilic, with a total run of 2 min. Quantification of the results was performed with isotopic dilution (
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Date
2011-02-15
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Peer reviewed scientific article
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Keywords
Accreditation, alternative, analysis, AS, Calibration, chromatography, detection, effect, fat, food, function, IS, Limit of Detection, Mass, Mass Spectrometry, matrix, method, milk, observed, PRODUCTS, Quantification, RANGE, Reproducibility, Residue, result, results, standards, Tandem Mass Spectrometry, Test, tests, treatment, ultrasound, UPLC